Why implement universal leukoreduction?

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Is there justification for universal leukoreduction?

The Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH), the institution that represents the Associação Médica Brasileira (AMB) in respect to hematology, transfusion therapy and cell therapy in Brazil hereby states: Prospective randomized studies have not demonstrated any positive clinical impact with the universal use of blood components in which the initial number of le...

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Universal prestorage leukoreduction in Canada decreases platelet alloimmunization and refractoriness.

Randomized controlled trials have shown a reduction in platelet alloimmunization and refractoriness in patients with acute leukemia (AL) with the use of poststorage leukoreduction of blood products. Universal prestorage leukoreduction (ULR) of red cell and platelet products has been performed in Canada since August 1999. We conducted a retrospective analysis of 13 902 platelet transfusions in 6...

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Universal leukoreduction of cellular blood components in 2001? No.

Leukocytes are known to have a number of biologic effects associated with allogeneic blood transfusion ❚Table 1❚. The potential clinical importance of these effects, which are the focus of current debate over the merits of “universal” leukocyte reduction (leukoreduction; cellular components with <5 × 106 leukocytes) include the following: febrile-associated transfusion reactions (FATRs), transf...

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To filter blood or universal leukoreduction: what is the answer?

The safety of the blood supply has been a concern over the past 20-30 years because of the transmission of infectious diseases. Blood is still routinely tested for viruses, and leukoreduction is an effective strategy to reduce the transmission of cell-associated viruses. Clinically, the benefits of leukoreduction include decreases in transfusion reactions, HLA alloimmunization, infections, feve...

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Universal leukoreduction of cellular blood components in 2001? Yes.

During the past 100 years, transfusion medicine has focused on introducing improvements in technology to increase the safety of blood transfusion. The initial obstacle to safe transfusion was the problem of acute hemolysis. 1,2 During the first 8 decades of the 20th century, much attention was given to compatibility testing, such that, by the latter decades, incompatible transfusions became inc...

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ژورنال

عنوان ژورنال: Hematology/Oncology and Stem Cell Therapy

سال: 2008

ISSN: 1658-3876

DOI: 10.1016/s1658-3876(08)50042-2